Ovarian metastases of colorectal and duodenal cancer in familial ...

Ovarian metastases of colorectal and duodenal cancer in familial adenomatous polyposis.

Fam Cancer. 2012 Sep 1;

Authors: Crobach S, van Wezel T, Vasen HF, Morreau H

Abstract

Metastases to the ovary occur in 0.8-9.7?% of colorectal cancer (CRC) cases (Hanna and Cohen in Clin Colorectal Cancer 3(4):215-222, 2004). The need to combine surgical resection of the primary tumor and bilateral oophorectomy is a matter of debate (Erroi et al. in J Surg Oncol 96(2):113-117, 2007). In a consecutive multi-hospital cohort of 30 CRC metastases to the ovary we came across four female patients (13?%; 95?% CI 3.6-34.1) with familial adenomatous polyposis (FAP). This number is high since the estimated incidence of FAP CRC is far below 1?% of all CRC and the expected incidence of FAP CRC that metastasized to the ovaries would thus be almost zero. In a second screen in nationwide databases we found that ovarian metastases occurred in at least 15?% of female FAP CRC cases. We provide now first evidence that especially in female FAP CRC patients bilateral oophorectomy during surgery should be discussed.

PMID: 22941256 [PubMed - as supplied by publisher]

Source: http://ovariancancerandus.blogspot.com/2012/09/ovarian-metastases-of-colorectal-and.html

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