Basic Things To Remember When It Comes To Self Help | Balanced ...

Posted on March 31, 2012
Filed Under Self Improvement |

Everyone has those problems in life that can be embarrassing to talk about, even to those who are professionals in the field. However, fear not, because self-help can be an effective way to manage your personal problems as well. Here you will find some great resources for self-help. Make use of these self improvement tips to know how to things to say to get your ex back from today onwards. Why wait? Read more tips below.

A key to personal development is setting priorities and developing a game plan. Setting priorities enables you to focus on what is important and eliminates wasted time on things that are not essential to reaching your goals. Having a game plan will reduce stress and help make big goals more manageable.

A key to success is learning how to take personal responsibility for mistakes. Instead of playing the blame game, acknowledge your mistakes, learn from them than move on. Taking personal responsibility for your actions is actually very liberating. You will soon feel like you are the one in charge of your own future and it will be easier to make decisions.

Find a mentor. One of the most powerful forms of learning is by mirroring best practices of those who are already where you want to be. Find someone that you want to emulate and study their lives. If it is realistic to approach this person, reach out to them and ask them for some one-on-one time. If you do get personal time with your mentor, come in prepared with relevant questions you want to ask. Otherwise, you will just be wasting your time and theirs.

Be wary of how you treat people. Being unnecessarily cruel to others almost never works in your favor. Make friends when you can. If you simply cannot bring yourself to get along with someone you should, at the very least, try and form some sort of civil relationship with them.

A great personal development tip is to know as much as you can about physics. Understanding physics is crucial to understanding earthly matters because you can?t understand these matters without knowing a little about heavenly matters. Knowing about physics in the present will help you learn beyond them in the afterlife.

Regardless of whether you work or go to school, it is important to try to maintain an assertive personality. If you are not strong, you may get walked over, which could lower your confidence and increase the level of anxiety that you face. Be strong and confident to reduce your worries.

If you are serious about personal development to improve your life, it is better to pick one small thing that you care about passionately and take small actions to demonstrate your passion than it is to form grandiose plans to save the world. Choose an improvement that you value and the doing will be easy.

A great tip that can help you with your personal development goals, is to surround yourself with people who are positive and supportive. If you?re around negative people all the time, it can be hard for you to make any positive changes. Being around positive people can help a lot.

Enunciate your words! Don?t be one of those people that stand on the edge of a group talking for what seems like hours and no one even realizes you are there! Choose your words carefully and speak clearly, so that everyone can understand. You can?t be appreciated unless you are heard and understood!

Making lists can help you to find serenity. Knowing what needs to be done can help you to relieve a lot of stress because you will not be spending time trying to remember what you wanted to do that day. It will help you to feel like you have a plan and know what to expect throughout the day which makes life less hectic.

Live what you want to achieve. Your goals and core beliefs should become a daily part of your life. Be sure to identify ways you can make expressing your core values a daily part of your life. This will enable you to stand by your convictions and make a difference in your life and those around you.

Look the part! Clothing choices are an important part of your image. If you volunteer to assist at your child?s school event, dress in a way that instills confidence and shows school spirit. On the other hand, if you are in charge at greeting attendees at an important work conference then you should likely dress more professionally.

Personal development is a very important thing to strive towards. Try to come up with a goal. A good example would be to start saving money. This is important because you can learn to develop your impulse control. Start by saving when you would usually spend on things you do not need. For instance, every time you would buy something out of a vending machine, put that into a bank account. By developing good spending habits, you will develop great personal habits.

After reading this article you should feel much more prepared for increasing your personal worth through development. Use this advice in your day to day life and you will quickly see your efficiency increasing. This can be applied as much to your personal life as it can to your professional life. Learn more about ways to lose weight faster by understanding more about post workout supplements from today onwards using the tips above.

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?Google?s Grand Plan: The search company no longer dabbles in exotic ideas. Now, it?s all business,? by Farhad Manjoo. Manjoo says that since Larry Page returned as Google?s CEO, ?Google is now a bolder, more disciplined, more ferocious combatant in the Valley?s tech wars.? And he garners four insights from a Google insider on the internet giant?s determined new path.

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Feds, 5 states to push for Great Lakes wind farms

TRAVERSE CITY, Mich. (AP) ? The Obama administration and five states have reached an agreement to speed up approval of offshore wind farms in the Great Lakes, which have been delayed by cost concerns and public opposition.

Under the deal, which administration officials disclosed to The Associated Press ahead of an announcement scheduled for Friday, state and federal agencies will craft a blueprint for speeding regulatory review of proposed wind farms without sacrificing environmental and safety standards. The Great Lakes have no offshore wind turbines, although a Cleveland partnership announced plans last year for a demonstration project that would place five to seven turbines in Lake Erie about 7 miles north of the city, generating 20-30 megawatts of electricity.

Offshore wind projects have been proposed elsewhere in the region, including Michigan and New York, stirring fierce debate.

Critics say they would ruin spectacular vistas, lower shoreline property values and harm birds and fish. New York Power Authority trustees last September abandoned a plan for private companies to place up to 200 turbines, each about 450 feet high, in Lakes Erie and Ontario. The Canadian province of Ontario in February 2011 ordered a moratorium on wind energy development in its Great Lakes waters to allow more study of environmental issues.

Supporters describe the lakes' winds as a vast, untapped source of clean energy and economic growth.

"This agreement among federal agencies and Great Lakes states is a smart, practical way to encourage the development of homegrown energy that will create jobs, power homes and reduce pollution in American communities," said Nancy Sutley, chairwoman of the White House Council on Environmental Quality.

Administration officials said the region's offshore winds could generate more than 700 gigawatts ? one-fifth of all potential wind energy nationwide. Each gigawatt of offshore wind could power 300,000 homes while reducing demand for electricity from coal, which emits greenhouse gases and other pollutants, according to the National Renewable Energy Laboratory in Golden, Colo.

Public resistance and logistical problems would pose formidable obstacles to approaching those levels. Yet harnessing only a small portion of the Great Lakes' offshore wind could generate thousands of jobs, officials said.

Illinois, Michigan, Minnesota, New York and Pennsylvania signed the agreement. The other three states with Great Lakes coastlines ? Indiana, Ohio and Wisconsin ? declined invitations but could join the partnership later, an administration official said.

The agreement is modeled after another between the federal government and Eastern states designed to support wind energy production in the Atlantic and encourage investment in new offshore wind technology.

"This agreement will enable states to work together to ensure that any proposed offshore wind projects are reviewed in a consistent manner, and that the various state and federal agencies involved collaborate and coordinate their reviews," Pennsylvania Gov. Tom Corbett said.

Illinois Gov. Pat Quinn said developing offshore wind energy would "promote economic development and create jobs, while reducing our dependence on foreign energy sources."

Among 10 federal agencies taking part are the Pentagon, the Department of Energy, the Environmental Protection Agency, NOAA and the U.S. Fish and Wildlife Service.

Developers would need state and federal approval to establish offshore wind farms. State governments own the Great Lakes bottomlands within U.S. territory, while a permit from the U.S. Army Corps of Engineers would be required to erect the turbines and all 10 federal agencies would review the plans.

Associated Press

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Source: http://news.yahoo.com/h-m-launching-retail-chain-2013-101043587.html

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Justin Bieber Promises Fire And Ice In 'Boyfriend' Video

'I think people are going to be really surprised,' Bieber tells MTV News on the set of the 'unique' video.
By Jocelyn Vena, with reporting by Kelly Marino

Justin Bieber
Photo: MTV News

While much of Justin Bieber's "Boyfriend" video remains top-secret, MTV News scored a visit to the set Thursday night, and the teen superstar offered up some insight into what Beliebers will see when the clip drops.

"The concept of this video, I mean it's not like a steady concept," he explained on the Cali-based set in between shots. "It's not like 'Justin follows this girl to this spot.' No, it's a bunch of amazing scenes: Like a fire scene, we have an ice scene."

He continued that the video will also include some of his very fine dancing skills. "It's kind of like bouncing back and forth," he said. "And then there's scenes of me and just a bunch of girl dancers, and just some great shots, great artistic shots, great shots of me smiling. It's fun."

Bieber and Tilley have worked together several times in the past, including on the VMA-nominated "U Smile," as well as "Never Let You Go," "Fa La La" (with Boyz II Men) and Chris Brown's very cinematic "Next 2 U," which features Bieber.

"The video's really good. Colin has done a great job," he said. "The lighting has been amazing and everything's been so unique and I haven't seen anything like it. So, I think people are going to be really surprised."

"Boyfriend" is the lead single off Believe, expected to drop later this year. The song was co-produced and co-written by Mike Posner and Mason Levy. The album will also feature some production from Timbaland, Diplo and will.i.am.

What are you hoping to see on the "Boyfriend" video? Leave your comment below.

Related Artists

• Justin Bieber

Source: http://www.mtv.com/news/articles/1682156/justin-bieber-explains-boyfriend-video.jhtml

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Source: http://news.yahoo.com/catholic-college-cans-kennedy-speech-blames-bishop-192510597.html

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Source: http://www.flickrfolio.net/umbrellas-they-re-not-just-for-fruity-refreshments

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Disney Channel knocks Nickelodeon from top ratings perch

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Source: http://news.yahoo.com/disney-channel-knocks-nickelodeon-top-ratings-perch-161246468.html

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Airline crew member mental health in spotlight after captain's breakdown

Clayton Osbon, who had been flying for nearly 25 years, allegedly began yelling at air traffic controllers and later ran toward the cockpit door after getting locked out. He has been charged with interfering with a flight crew. NBC's Tom Costello reports.

By Rebecca Ruiz, Senior editor, msnbc.com

Two recent incidents in which airline crew members behaved alarmingly and had to be restrained by passengers have raised questions about when and how aviation workers are screened for mental health problems.

On Tuesday, JetBlue captain Clayton Osbon, 49, was locked out of the cockpit by his co-pilot after he began acting erratically on Flight 191 from New York to Las Vegas. The captain, since charged with interfering with a flight crew and now getting medical care, was upset when he couldn't get back into the cockpit and began yelling about an unspecified threat linked to Iran, Iraq and Afghanistan.

Osbon "became increasingly agitated," and several passengers grabbed the pilot, "tackled him to the ground" and sat on him, passenger Tony Antolino told TODAY's Ann Curry.

It is not yet clear if anxiety or mental health issues led to Osbon's behavior. JetBlue said in a blog post that it will not share further details about the captain's "private life."

Osbon's last medical exam was four months ago, the Federal Aviation Administration (FAA) told msnbc.com. "He has a clean record, no incidents or accidents and the FAA has not taken any type of enforcement action against him," the agency said in a statement.

JetBlue CEO Dave Barger called the pilot, who was suspended on Wednesday, a "consummate professional."

JetBlue CEO Dave Barger speaks out after a JetBlue flight made an emergency landing due to a pilot's mid-air meltdown.

Earlier this month, an American Airlines flight attendant was removed from a flight after becoming combative and talking about the airline's bankruptcy and 9/11 on the plane's public-address system. Officers were also told that the 43-year-old woman was bipolar and was not taking her medication at the time, according to a police report on the incident.

John Cox, an aviation safety consultant and former airline pilot, told the Associated Press that incidents in which pilots become mentally incapacitated during a flight are "pretty rare." He said he could only recall two or three other examples in the more than 40 years he has been following commercial aviation.

While uncommon, these incidents have shown how crew member mental health is an important aspect of flight security and can be exacerbated by the high-stress environment of commercial flying.

The FAA requires that airline pilots have a medical certificate, which must be renewed annually if the pilot is under 40 and every six months if the pilot is older than 40. To receive the certificate, pilots undergo a physical examination by an FAA-designated physician. A psychological assessment is not part of the evaluation, but the physician can order testing if deemed necessary. The pilots are responsible for disclosing all existing physical and psychological conditions and may have their certificate revoked if they withhold that information.?

The FAA grounds pilots who disclose that they are being treated for depression or request treatment. The pilot has to be "stable" for 12 months before returning to the cockpit.

A pilot undergoing treatment for depression is required to provide a report from a psychiatrist which details the diagnosis, course of treatment and possible side effects from medication. The pilot also has to submit to psychological testing and prepare a written statement describing his or her use of antidepressants.

The FAA can make an exception for pilots who take one of four antidepressants approved by the agency as safe to use for treating mild-to-moderate depression. In these instances, medical certificates are given on a case-by-case basis.?

Tony Antolino and Laurie Dhue, passengers aboard the JetBlue flight that made an emergency landing after the pilot had a mid-air meltdown, talk to TODAY's Ann Curry about the bizarre incident.

Of the 120,000 U.S. commercial airline pilots, 27 have taken advantage of the anti-depressant policy and have been permitted to fly while using the approved medications, according to the FAA. Anxiety disorders and medications are evaluated on an individual basis.

The FAA, which has said that depression "can lead to distraction and make it difficult for a pilot to focus," implemented the anti-depressant policy in 2010.?

?I?m encouraging pilots who are suffering from depression or using antidepressants to report their medical condition to the FAA,? said FAA Administrator Randy Babbitt in a statement at the time. ?We need to change the culture and remove the stigma associated with depression. Pilots should be able to get the medical treatment they need so they can safely perform their duties.?

The Air Line Pilots Association and the US Airline Pilots Association, both pilots' unions, have yet to respond to msnbc.com's requests for comment.

Dr. David Ballard, an expert on mental health policies in the workplace at the American Psychological Association, says the FAA's policy is fairly unusual because it must balance airplane and passenger security and the rights of the individual employee. Still, Ballard says, requiring employees to disclose mental health disorders can lead to a chilling effect and prevent them from seeking treatment in the first place.?

When addressed, a mental health disorder can be very treatable. "You obviously don?t want someone who is going to be unable to perform their job duties safely and effectively," Ballard said, "but just because someone has a mental health disorder, that doesn't mean they won?t be able to do their job well."

Unlike pilots, flight attendants do not undergo a medical examination, and airlines are not permitted to ask about mental health conditions. Flight attendants are certified by the FAA after completing a rigorous training program that emphasizes first-responder skills in emergency situations. Should a flight attendant seek treatment for a mental health condition, his or her FAA certification will not be endangered.

Corey Caldwell, a spokesperson for the Association of Flight Attendants, a union with nearly 60,000 members, says that training and a probationary period provide many opportunities to identify crew members who might have debilitating mental health conditions that could be triggered by tense situations.?

"I think it?s important to remember that the American Airlines flight attendant was a 23-year-veteran," said Caldwell. "Over two decades she'd been performing that [first responder] role. These two high-profile examples ... are not necessarily systemic of the population at large, but they do highlight extremely stressful situations [crew members] undergo on a daily basis."

Caldwell says that union members have increasingly reported in the past years that the stress of their profession is "escalating." Between the post-9/11 focus on security threats, the strain of airline bankruptcies and labor negotiations, and the fatigue that results from tighter schedules, the job now takes a greater emotional toll than it once did.

AFA offers members access to an employee assistance program, which provides mental health resources on request. Members can also report concerns they may have over the behavior or well-being of fellow attendants and, if needed, the AFA will get that individual help without involving airline management.

JetBlue and American Airlines crew members do not belong to the AFA, though JetBlue said on Wednesday that it does offer an employee assistance program, and that, "crew members are also able, and expected, to call a safety time-out should they need it, and the company will support them 100 percent."

"I don?t think these instances will stigmatize the profession," said Caldwell. "They?ll help shed light on the seriousness and stressfulness of this job on a daily basis."

The Associated Press and NBC 5 contributed to this report.

Related stories:

Rebecca Ruiz is a senior editor at msnbc.com and a Rosalynn Carter Mental Health Journalism Fellow.

Source: http://overheadbin.msnbc.msn.com/_news/2012/03/28/10903150-airline-crew-member-mental-health-in-spotlight-after-captains-breakdown

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Freedom from Chronic Pain - Health And Fitness Tips

Chronic pain is the body?s way of informing us that it?s not at peace; it is sick. It?s also a warranted way of getting our attention. A terrifically effective, safe and non-intrusive way we are able to respond to agony is by applying Emotional Freedom Techniques (EFT). Actually one of the much-publicised benefits of EFT is pain alleviation.

As an EFT Practitioner, and Progressive Emotional Release (Pro-ER) Practitioner focusing on major illness, I work with people experiencing lingering physical, emotional, or psychological agony on a daily basis. Indeed, in 2003 when wheelchair-bound and seriously ill with Chronic Fatigue Syndrome (CFS), I wrestled with chronic pain too.

Gary Craig, the originator of EFT claims: ?The cause of all negative emotions is an interruption in the body?s energy system.? That is, a idea or memory triggers a interruption in the body?s energy system and this is experienced as psychological or physiological agony. While experiencing or concentrating on a particular problem, and tapping on the meridians that carry the energy, interruptions are cleared and ordinary function can resume. When EFT is applied reasonably, a cognitive shift takes place, which frees us from our negative emotions, thoughts and sentiments, restoring health and well-being.

Our unresolved negative emotions contribute significantly to most physical pains and diseases. When we are unable (for whatever reason), to express emotions like wrath, resentment and grief, they?re swallowed and repressed. They later show up in the body as agony and illness.

At the time I became ill, I did not understand how to resolve the hurt and resentment I was experiencing, because of problems at work and in my relationship. Plus, I was coping with the sudden death of my aunt to whom I was very close. The subsequent indications of intense fatigue, joint and muscle discomfort, brain fog, noise and light sensitivities, and digestive abnormalities actually attracted my attention ? my body was screaming out to get heard.

Seven months later when I was introduced to EFT, my consultant helped me release many stressful memories, which had led on to the hurt and antagonism I was hanging on to. Extremely swiftly, I was able to review formerly troublesome memories with neutrality and acceptance: I was still aware they had occurred; only my perspective had modified. Concurrently, I realized that certain symptoms were easing or disappearing, particularly, my joint and muscle agony, and the difficulties with my digestion and food intolerances.

Unlike many types of talk treatment, with EFT it is not important to dig deeply and relive unpleasant memories in fine detail. Rather, what appears to occur is that once one or two upsetting memories are cleared, other related memories are slumped without a need to be worked on in particular.

Peeling away the complicated layers of chronic illness and agony can be complex and delicate. There may be masses of ?unpleasant memories? to work thru which have resulted in repressed emotions and later sickness. Also , on a subconscious level, a chronic illness or pain can serve a person very well. All of a sudden they?ve a purpose. When a person is seriously sick or suffering chronic pain, there are fewer expectancies put on them, so they can feel safer: they no longer have to prove themselves, achieve success or be ?perfect?.

When I begin to work with a client coping with chronic pain I ask particular questions designed to get some insightful clues regarding the root cause of the pain. One such query is:

?What is the upside of holding on to this pain/illness??

Naturally, the first reaction is, ?There is no upside, I?d like to be healthy!? but when the issue is reframed to suggest, ?What would be the downside to recovering?? the client tunes in to how their life was prior to becoming ill.

When I asked a client suffering from Trigeminal Neuralgia (intense facial discomfort causing spasm) this question lately, in her first personal session, she answered, ?If I recovered, I?d need to be perfect again and I would have to look after and help everyone.? It transpired that as one of 6 children she had been expected to look after her siblings because her mother was quite sick for time. She had felt acrimony as a result. She had continued this role of looking after everybody else when she married and had a family of her own, always putting herself second. Now, subjected to intense pain, she was, finally able to be looked after and aided by others. She targeted on the acrimony and the memory of her childhood, and we applied EFT till she no longer felt any emotional power or reaction to the experience. At the end of the session, she told me the desperateness she?d felt about her facial discomfort was ?lighter? and ?didn?t seem to matter as much now?. Naturally, there is still more work to be done addressing her inability to ask for what she required (making her body ask for her) and in organising her life and relationships so that she was never having to ?give ? all the time, but could also ?receive?.

Another question which offers discernment is:

?If there had been a person or an event in your life which you?d just as soon skip, who or what would it be??

One client told me that she would never have taken that vacation to Florida as a young woman, as it had been the catalyzing agent for her health issues. Just after returning, she was assessed with CFS and later , multiple chemical sensitivities and ulcerative colitis. She had repressed emotions of outrage and regret ever since. Forty years after, she was housebound and still seriously sick. We used EFT on the holiday memory. Not only were we able to neutralize the negative principles she?d felt about herself because of the holiday, but she was able to see new possibilities for her future. Since that time, we have worked together closely and now she?ll put up with more wide-ranging foods, is able to leave the house regularly, exercises, and has a part-time job writing.

In the end if the right questions are asked, we?re able to the root cause quicker and get the answers we require to heal the issue. Furthermore, if we may be able to resolve the emotional reasons for physical sickness and chronic pain, surgery may not be obligatory.

Annabel Fisher is a licensed NLP Practitioner and runs a successful EFT practice. If you are suffering with chronic illness, fears and fears, weight issues and more; book a free 30 minute telephone consultation.
You can get your free ?The Necessities of EFT Guide? plus one hour EFT Q&A audio recording by signing up for her newsletter at: http://www.theefthealingcentre.com.

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Technorati Tags: Annabel Fischer, chronic pain, EFT Practitioner, Emotional Freedom Techniques, emotions, healing, health and fitness, Pain Management

Source: http://healthandfitnesstips.biz/freedom-from-chronic-pain-eft-identifies-and-melts-the-basic-causes

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Breitbart.com's Dan Riehl Blames Obama for Random Twitter Posts, Commenters Spew Hatred (Little green footballs)

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Summary Box: Spain edges toward economic abyss

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Source: http://news.yahoo.com/summary-box-spain-edges-toward-economic-abyss-181041542.html

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User:Investing in gold 2012 - opensourceCMS MediaWiki Demo

[unable to retrieve full-text content]When compared with traditional investment, gold and silver bullion is more reliable as the market place is simply by no means as volatile and unstable as, say, real estate or stocks and bonds markets. how to invest in gold Silver and gold ...

Source: http://demo.opensourcecms.com/mediawiki/index.php/User%3AInvesting_in_gold_2012

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Make Money Online Successfully ? 5 Internet Marketing ...

[unable to retrieve full-text content]However, a lot of people don't know that business internet marketing might not be costly- it just has always to work. With regard to small business owners who want to figure out business marketing online alone, allow me to share a few internet ...

Source: http://www.kitchenappliance-reviews.org/make-money-online-successfully-5-internet-marketing-suggestions-small-businesses-proprietors-have-to-know/

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Injuries Occurring At Schools In New Orleans Personal Injury Lawsuits

by Gertler Law Firm on March 27, 2012

The schools of New Orleans have the difficult task of not only educating thousands of children, but also attempting to maintain an environment that is safe for all students.? While there is no absolute bar to suing a school when its employees fail in their duty to properly supervise students and provide a safe environment, any matter involving an injury at a school should be evaluated by an experienced personal injury attorney to determine its merits.

Schools do have a duty to provide reasonable supervision over students through their employees.? They are not, however, expected to be perfect in their supervision of students.? The Louisiana courts have noted that constant supervision of all students is neither possible nor required, and that the degree of supervision required must be evaluated based on the specific circumstances of the particular case.

As a result, any time a lawsuit against the school is being considered, several factors must be carefully evaluated.? These include not only whether the school was providing supervision, but also what sort of activity led to the injury, whether the possibility of injury could have been reasonably foreseen by the school employees, and the capacity of a student of a given age to understand the risk of injury.

Whether the school could actually be considered to be in control of the student at the time of the injury is also critical to any lawsuit involving a school.? While a school will generally be considered to have custody of a student when in class or on the school bus, they may not have a legal requirement to provide supervision during certain extracurricular activities or for students walking to or from school.?

An experienced personal injury attorney will carefully scrutinize all of the factors surrounding an injury when determining whether the school is a proper party to proceed against.? Even if compensation cannot be sought from the school, there may be other parties who could be held responsible for the child?s injury.

If your child has suffered an injury and you have any questions regarding your legal rights, we would be happy to take your call.? We can be reached at 504-355-0057 or 855-GERTLER.

Source: http://louisiana-injury-law-answers.com/2012/03/if-my-child-is-injured-at-school-can-i-sue-the-school/

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To drive infections, a hijacking virus mimics a cell's signaling system

Monday, March 26, 2012

New biological research reveals how an invading virus hijacks a cell's workings by imitating a signaling marker to defeat the body's defenses. By manipulating cell signals, the virus destroys a defensive protein designed to inhibit it. This finding, from studies in human cell cultures, may represent a broader targeting strategy used by other viruses, and may lay the scientific groundwork for developing more effective treatments for infectious diseases.

"Learning details of how cells respond to viruses helps us to understand key cellular machinery better," said study leader Matthew D. Weitzman, Ph.D., of the Center for Cellular and Molecular Therapeutics at The Children's Hospital of Philadelphia. "This study tells us how a virus overcomes intrinsic host defenses. In this case the virus mimics signals used during normal DNA repair mechanisms."

The study team, formerly based at the Salk Institute for Biological Studies in La Jolla, Calif., published their current findings online March 8 in Molecular Cell.

Biologists have long known that viruses hijack cellular processes to replicate themselves, while host cells have evolved intrinsic defense systems to resist viral invasion. To replicate, viruses must deliver their own DNA into a cell's nucleus, so a viral infection entails a conflict between two genomes?the DNA of the host cell versus the foreign DNA of the virus.

Viruses mount their attack by interacting with specific cell proteins as a way of penetrating the cell's defenses. "In this study, we asked how the herpes simplex virus finds the specific proteins that it interacts with," said Weitzman. "By describing the mechanism of this particular interaction between a virus and a cell protein, we have pinpointed key regulators of a cell's processes, and shed light on how a cell regulates its defenses."

This laboratory study focused on herpes simplex virus type-1 (HSV-1), a common human virus that results in recurrent infections alternating with inactive periods. Like other viruses, HSV-1 is known to manipulate cellular processes in order to infect cells, but the specific mechanisms by which it acts on the DNA repair pathway were previously unknown.

Weitzman's study team was studying a viral protein called ICP0 that overcomes host defenses by targeting cellular proteins for destruction. They found that ICP0 exploits phosphorylation, a chemical mark that is often used in cells to promote interactions between proteins, especially as part of the cellular signaling response to DNA damage. In HSV-1 infection, the phosphorylation signal on ICP0 attracts a cellular DNA damage response protein, RNF8, which binds to the false signaling marker and is then degraded. Because RNF8 normally inhibits viral replication, its destruction leaves the cell vulnerable to HSV-1 infection, as the virus takes over the cell's machinery.

The researchers also found that ICP0 exploits the same phosphorylation signal to bind to other cellular proteins in addition to RNF8, a hint that it may play a broader role in defeating antiviral defenses and manipulating cellular machinery. Weitzman will continue to investigate HSV-1 infection in neurons and in animal models. He also plans to extend his research into other viruses, which may act on different pathways than HSV-1 does. "Ultimately," he added, "better knowledge of molecular mechanisms in infection may suggest strategies to interrupt the viral life cycle and treat infections."

###

Children's Hospital of Philadelphia: http://www.chop.edu

Thanks to Children's Hospital of Philadelphia for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/118719/To_drive_infections__a_hijacking_virus_mimics_a_cell_s_signaling_system

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U.S. spending cuts bite in Paul Ryan's home town

JANESVILLE, WI. (Reuters) - Republican Representative Paul Ryan's budget-cutting vision has made him a hero to conservatives across the country. It's less popular in his home town.

As Ryan's proposal to slash taxes and spending started to move through Congress last week, local officials in this humble Rust Belt city scrambled to recover from last year's cutbacks.

The U.S. Department of Housing and Urban Development had clawed back $344,000 from the city's affordable-housing fund, so the Janesville Community Development Authority voted to drain its reserves to keep its 525 families in the program.

The city won't have to put anybody out on the street, probably. But there is no cushion left.

Ryan has called for belt-tightening to head off fiscal disaster in the years to come, but Janesville is already familiar with austerity.

There's less money for job training, health clinics and the food bank; higher property taxes and higher car fees; larger school class sizes, crumbling roads, fewer firefighters.

"It's like being in a fight against five or six people. Every time you turn around you're getting punched from a different direction," said City Council President Russ Steeber.

In the 14 years since voters in the southeast corner of Wisconsin first sent him to Congress, Ryan has emerged as perhaps the country's foremost fiscal conservative. Only 42, he is frequently mentioned as a possible vice presidential pick.

His latest budget plan, unveiled Tuesday, will serve as a rallying cry for Republicans as they try to win control of the White House and both chambers of Congress in the November 6 elections.

Democrats hope voters will be spooked by Ryan's proposal to partially privatize Medicare, the popular health plan for retirees.

"When people sent Paul Ryan to Washington, D.C., they certainly didn't send him there to end Medicare," said Democrat Rob Zerban, who hopes to unseat Ryan in the fall.

Ryan's district, which encompasses struggling cities as well as affluent lake resorts and blue-collar Milwaukee suburbs, has grown more Democratic in recent years.

Though voters here backed Democrat Barack Obama in the 2008 presidential election, Ryan has continued to win re-election by wide margins and Democratic officials say it will be a challenge to unseat him this year. The Cook Political Report, a nonpartisan tip sheet, rates the race "solidly Republican."

CLOSE TIES

Ryan has maintained close ties to this city of 60,000 even as his national celebrity has grown. He returns most weekends to spend time with his wife and three young children and local leaders say they see him regularly out and about.

"He is extremely plugged in," said John Beckford, president of Forward Janesville, a local business group. As in Washington, he is widely admired for tackling the country's long-term debt.

Though Democrats have hammered Ryan on Medicare and tax cuts that would benefit the wealthy, they have devoted less attention to other proposed spending cuts.

Under Ryan's plan, the government would spend $3 trillion less than Obama over the coming 10 years on domestic programs. That's one-third percent less for Medicaid, the health plan for the poor; one-quarter less for transportation, and one-third less for education. Tax breaks and food and housing assistance for the poor would shrink by 16 percent.

His budget, like the rival vision outlined by Obama in February, has no chance of becoming law as long as Democrats and Republicans split power. But no matter who controls Washington after the November elections, continued austerity is likely to be the rule under a 10-year, $1 trillion deficit-reduction plan passed last year.

Even relatively modest reductions hit hard in Janesville, which is still digging out from the closure of a General Motors plant four years ago that left 4,000 people out of work.

Businesses are pushing to widen Interstate 90, an effort that would rely on federal money. Southern Wisconsin Regional Airport also is counting on federal dollars in the next 10 years to cover 90 percent of a planned $5 million runway upgrade.

Federal job training grants helped many of the laid-off GM workers learn new skills at Blackhawk Technical College, and one in five students there currently rely on federal student loans or grants, according to a school official.

Ryan's proposed Medicaid cuts would strain local hospitals, which already lose money on every patient they see under the program.

"Our mission is to provide health services to the communities where we have a presence," said Rich Gruber, a vice president at Mercy Health System. "If I don't have a financial margin, I'm never going to be able to accomplish that mission."

Janesville was hammered by the 2008-2009 recession. The GM plant closure sent shock waves through the ecosystem of parts suppliers and other employers that depended on the massive facility for business.

Food banks and other local charities struggled to keep up as demand swelled and private donations plummeted. The city's rental-assistance program, funded by federal money, stopped accepting new applicants two years ago.

Things are looking up lately. The unemployment rate has fallen to 8.3 percent, still well above the statewide average but well below the March 2009 peak of 13.9 percent. A startup company recently announced plans to build an $80 million medical-isotope plant, and hospitals are expanding.

DIGGING OUT

Still, enormous challenges remain as families struggle to climb back into the middle class.

One in 25 school children was homeless at some point last year, and half qualify for free or reduced lunches. Manufacturers are hiring again, but many of the jobs pay $9 per hour, far short of the $20 to $30 hourly wage paid by GM.

Many workers don't have the communications or math skills that better-paying jobs demand, and federal job training funds are projected to shrink 6 percent to 12 percent in the coming fiscal year. There are 8,000 fewer jobs now than there were a decade ago.

"At one point in time I probably would have said we need to scale back government. Now I see people that are at a loss, they don't know where to turn," said Robert Borremans, the head of the Southwest Wisconsin Workforce Development Board, which oversees job-training efforts in Janesville.

Not everyone shares this view. Several local business leaders said they agreed with Ryan's argument that lower taxes and fewer regulations, rather than continued federal spending, would get the economy moving.

Bill Sodemann had to lay off half of his employees at his telecommunications firm during the height of the recession. As head of the Janesville school board, he's made painful decisions there as well.

The school district had to cut 110 of its 1,400 staff positions last year, raise class sizes and hike fees for high school sports after the state legislature slashed its contribution. More painful cuts loom next year.

'LIKE A DRUG DEALER'

Federal contributions also fell last year by 33 percent as stimulus money dried up. Sodemann says the burst of federal money only postponed the district's day of reckoning.

"They give you money and hook you on a program and say, 'OK, now it's gone, you fend for it," he said. "It's kind of like a drug dealer, I guess."

Sodemann points to a new pre-kindergarden program as an additional drain on resources. Parents who want to put their kids in the program should pay for it themselves, he said.

"Just because it's beneficial doesn't mean government should pay for it," he said.

Several miles south of Sodemann's downtown office, four-year-old children enrolled in the program stream off a playground into a cheery day-care facility run by a nonprofit group, Community Action Inc.

Early-childhood programs like these have been shown to boost school performance and reduce crime. More than two-thirds of the program's is covered by federal subsidies, which allow parents to enter the workforce rather than remaining at home and mired in poverty, nonprofit officials say.

Community Action officials choose their words carefully when asked about Ryan. He's willing to listen to their concerns, they say, even as he makes clear that his focus is on federal fiscal issues rather than the immediate needs of his community.

"It's a question that doesn't come to the top of his list," said Lisa Forseth, Community Action's executive director.

Donna Hays, a nurse practitioner who runs the nonprofit's women's health center, is more direct as she puts on her lab coat and stethoscope.

"We sometimes have to ask him if he remembers where he came from," Hays said.

(Editing by Alistair Bell and Vicki Allen)

Source: http://news.yahoo.com/u-spending-cuts-bite-paul-ryans-home-town-051415397.html

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