Yahoo announces six original shows, WWE streaming partnership

Innovation Takes Center Stage at Yahoo!'s 2013 NewFront

Yahoo! Unveils New Original Programming, Premium Content Deals, and Innovations in Advertising

NEW YORK--(BUSINESS WIRE)-- A four-inch-tall crime fighter, a pair of Hollywood starlets who abuse their personal assistant, and a celebrity who explores the "first times" of fellow stars -- those are just a few highlights of the new programs Yahoo! (Nasdaq: YHOO) is unveiling tonight at its Digital Content NewFront in New York. In a star-studded event that will feature Ed Helms, Zachary Levi, John Stamos, Morgan Spurlock, Cheryl Hines, Rachael Harris and others, Yahoo! is announcing its new lineup of video shows, new partnerships to expand content offerings, and new opportunities for advertisers to be at the center of users' daily habits. The night will be capped by a special performance from The Lumineers, with a live stream of the 30-minute set on Yahoo! Music (http://music.yahoo.com).

"Yahoo!'s unique mix of content and technology leads not only to powerful and personalized experiences for our users, but also to greater distribution for our partners and higher return for our advertisers," said Henrique de Castro, chief operating officer, Yahoo!. "What we're showing tonight signals where Yahoo! is headed: beautiful product experiences, exciting new content, big partnerships with the largest media brands, and extraordinary new ad experiences."

"In the last year, we have more than doubled the original video programming on Yahoo! to become one of the Web's largest content publishers," said Erin McPherson, Yahoo! vice president and head of video. "The new shows and partnerships we're announcing at Yahoo!'s NewFront demonstrate how we are building scale, reaching more targeted audiences, and innovating with content."

NEW ORIGINAL PROGRAMMING

Yahoo! has already established a vast audience for original premium women's lifestyle shows and original comedy programming from top studios, production companies, and the award-winning Yahoo! Studios. A new lineup of comedy and lifestyle shows will expand that portfolio.

New Comedy Shows (coming to Yahoo! Fall 2013):

"Tiny Commando" -- Ed Helms created and stars, along with Zachary Levi, Gillian Jacobs, and some of the biggest names in comedy, in the Principato-Young Entertainment production, "Tiny Commando," an action-packed series following a four-inch-tall private investigator who uses his awesome fleet of vehicles to fight crime.
"We Need Help" -- In Vuguru's "We Need Help," creators, producers and stars Cheryl Hines and Rachael Harris exploit their shared personal assistant in the series produced by Principato-Young Entertainment and Steve Carr, and directed by Hines.
"Losing Your Virginity with John Stamos" -- John Stamos interviews celebrities about their first sexual experiences in "Losing Your Virginity with John Stamos," co-produced by Warriors Poets and executive produced by Morgan Spurlock and John Stamos.
New Lifestyle Shows (coming to Yahoo! later this year):

"Fashion Recipe" -- Celebrity stylist Brett Alan Nelson shows you how to get the most from one particular article of clothing.
"Cinema & Spice" -- Julianna Strickland and Natasha Feldman explore food and film while teaching viewers new cooking skills and decorating ideas.
"Grill Girls" (working title) -- A new grilling show featuring Chef Megan Mitchell sharing her grilling secrets and tips for everything from steaks, to peaches and pizza.
Yahoo! will program its new Fall comedy lineup -- including previously-announced shows, "The Fuzz" from Vuguru, and "Ghost Ghirls" from Shine America and Electric Dynamite -- in a new way for the company. Based on insights from user data, Yahoo! is making all episodes available at once in a "binge-viewing" format, providing viewers with premium programming options beyond traditional TV.

NEW PARTNERSHIPS

In addition to the recently announced "Saturday Night Live" partnership, Yahoo! is partnering with popular consumer brands to add breadth to its existing portfolio of partner content, enhance Yahoo!'s cross-screen experience, and attract new audiences.

Yahoo! and WWE Tag-Team Video Distribution

Yahoo! will be the premiere global video distribution partner for WWE, with a dedicated hub on Yahoo! for all WWE content. Beginning summer 2013, the following WWE content will be available on Yahoo! globally:

Monday Night Raw pre-show: A 30-minute pre-show to each new Monday Night Raw will be exclusive to Yahoo!.
Original programming: Two weekly series of 50 episodes per year will be produced exclusively for distribution on Yahoo!.
Premium archive: Yahoo! will have exclusive access to WWE archives of historical full matches, shows, highlights and other events.
Additional live events: Yahoo! will air live, pre-show content for every pay-per-view event.
Clips from current TV programming: Clips from all WWE television programs will now be available on Yahoo!.
ABC News and Yahoo!: Phase Two

The Yahoo!-ABC News Network, the #1 source of news and information online, is excited to announce the next phase of their partnership, which first launched in October 2011. Three of ABC News' top franchises - Nightline, World News With Diane Sawyer, and Good Morning America - are coming to Yahoo! as unique, daily, digital-native extensions.

"World News Beyond the Headlines" -- Diane Sawyer and a team of world-class correspondents tell you what you didn't know about the news of the day. Each day they'll deliver that extra, interesting nugget. The show will also feature popular franchises such as Person of the Week.
"Nightline: Online" -- A smart take on the news stories that start conversations. On a daily basis, the team will provide exclusive, first-look content to the Nightline community, on topics ranging from entertainment to pop-culture trends, to breaking news and international expos?s.
"GMA Live" -- GMA Live kicks into full swing in front of a live studio audience, every weekday morning. This digital-only show continues the morning conversation with segments like GMA Rewind, the Play of the Day, EXTRA, and Exclusive Deals.
Yahoo! Finance and CNBC: "Talking Numbers"

Yahoo! Finance and CNBC will debut their third original co-production, "Talking Numbers." This new incarnation of "Talking Numbers," originally a successful franchise on CNBC's Closing Bell, will bring the best of broadcast to an unmatched audience online. Debuting in May, "Talking Numbers" takes a 360-degree approach to trading, highlighting the best investment opportunities by analyzing stocks from both a technical and a fundamental point of view. The ultimate goal: teach viewers not just what to buy, but how to buy, by harnessing both technical and fundamental data points so they can become better investors. Together, Yahoo! Finance and CNBC have created compelling content including shows such as Off the Cuff and Big Data Download.

Yahoo! and Conde Nast

In a new partnership, Yahoo! will distribute Conde Nast Entertainment's video content, inspired by the iconic Conde Nast brands, across the Yahoo! network. The partnership brings engaging lifestyle content to Yahoo!, while adding scale to Conde Nast Entertainment's video series.

NEW ADVERTISER OPPORTUNITIES

NewFront attendees will see new offerings that make the advertiser experience on Yahoo! more relevant, provide more reach, and weave brands into the creative canvas:

Yahoo! Stream Ads, a performance-based native advertisement embedded in the personalized content stream on the new Yahoo! homepage.
Billboard, an ad positioned at the top of the Yahoo! homepage and designed to enhance the user experience with rich and immersive interactions.
Yahoo! is offering a new video ad buying method that blends its own topical video channels with distribution partners' video content to create 18 new category-specific channels that deliver a new level of contextual relevance for advertisers.
With its new content and technology offerings, Yahoo! now has one of the most complete and effective video solution sets on the market. Brands can own a show with Yahoo!'s custom branded entertainment solutions, buy a category using 18 channels of contextually relevant content, and target an audience with Yahoo!'s industry-leading audience buying capabilities.

SHOW DESCRIPTIONS

Tiny Commando

Ed Helms became addicted to radio controlled toys at young age. Upon learning to pilot tiny helicopters, dune buggies, airplanes, boats and even motorcycles, Ed's backyard suddenly became a miniature Jerry Bruckheimer movie. Always underlying the fun was a delightful fantasy: "What if a little tiny guy was actually piloting this thing?" And thus "Tiny Commando" was hatched. Part action, part comedy, and part insane RC vehicle chase sequence, every episode is a bombastic thrill ride of miniature adrenaline! Produced by Principato-Young Entertainment

We Need Help

A Vuguru production, "We Need Help" takes place in the world of the rich and semi-famous, centering around a common problem: being stuck in a terrible job. Max is a struggling actor and needs work (and just one good showbiz connection wouldn't hurt). He agrees to take the job of being a personal assistant to actresses and friends Cheryl Hines and Rachael Harris (who created and produced the show and also play versions of themselves in the vein of "Curb Your Enthusiasm"). Needing the money to take classes, eat and pay the rent, he's willing to do things no 23-year-old man would ever do and still keep his integrity intact. Produced by Principato-Young Entertainment and Steve Carr and directed by Cheryl Hines.

Losing Your Virginity with John Stamos

Each week, John will visit a different celebrity to get the scoop on how it all went down the first time she/he "did it." Adding to the entertainment, viewers will be treated to humorous recreations using crude animation, stop-motion techniques, and the occasional Barbie Doll and/or sock puppet to help underscore the story. This is more than just a show about how celebrities lost their virginity; it's about who they were before they were famous; and what insecurities they faced during their teen years. Co-Produced by Warriors Poets & Executive Produced by Morgan Spurlock & John Stamos

Cinema & Spice

"Cinema & Spice" is an interactive cooking show showcasing Julianna Strickland and Natasha Feldman's mutual love for delicious, healthy foods and fantastic shows and movies. Join them in an exploration of food and film while learning new cooking skills and unique decorating ideas! Produced by Cinema & Spice, LLC

Grill Girls (working title)

Hosted by Chef Megan Mitchell, this grilling show features women who know how to grill, as they share their secrets for grilling to perfection. Episodes will cover standard grill fare such as grilling the perfect steak, and even grilling peaches and pizza, and explore little known facts that can help everyone enhance their grilling skills. Produced by Yahoo! Studios

Fashion Recipe

"Fashion Recipe" visits a different woman's closet each week with our celebrity stylist, Brett Alan Nelson, who examines how to get the most from a particular article of clothing (the pencil skirt, the little black dress, a blazer) or a killer accessory (scarves, bracelets, bags). This fast-paced, tip-filled program combines a look at fashion-forward trends with information and advice on how every woman can afford to bring them to life without breaking the bank. Produced by Full Picture

Source: http://www.engadget.com/2013/04/30/yahoo-announces-raft-of-original-shows-wwe-streaming-partnership/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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It takes 2 votes, but Minnesota Senate approves $1.8 billion tax bill (Star Tribune)

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China career boost can come with health risks

In this Feb. 28, 2013 photo, a giant electronic screen on Tiananmen Square shows an image of Tiananmen Gate under a blue sky as part of a propaganda video on a polluted day in Beijing. While the numbers are hard to quantify, executive recruitment consultants say they are noticing that it is becoming harder to attract top talent to China - both expats and Chinese nationals educated abroad. If the polluted skies continue, companies may have to fork out more money for their workers, settle for less qualified candidates or hire local workers instead of expats.(AP Photo/Alexander F. Yuan)

In this Feb. 28, 2013 photo, a giant electronic screen on Tiananmen Square shows an image of Tiananmen Gate under a blue sky as part of a propaganda video on a polluted day in Beijing. While the numbers are hard to quantify, executive recruitment consultants say they are noticing that it is becoming harder to attract top talent to China - both expats and Chinese nationals educated abroad. If the polluted skies continue, companies may have to fork out more money for their workers, settle for less qualified candidates or hire local workers instead of expats.(AP Photo/Alexander F. Yuan)

FILE - In this Jan. 12, 2013 photo, a man flies a kite near electricity pylons on a hazy day in Beijing. While the numbers are hard to quantify, executive recruitment consultants say they are noticing that it is becoming harder to attract top talent to China - both expats and Chinese nationals educated abroad. If the polluted skies continue, companies may have to fork out more money for their workers, settle for less qualified candidates or hire local workers instead of expats. (AP Photo/Alexander F. Yuan, File)

BEIJING (AP) ? Whitney Foard Small loved China and her job as a regional director of communications for a top automaker. But after air pollution led to several stays in hospital and finally a written warning from her doctor telling her she needed to leave, Small packed up and left for Thailand.

In doing so, the Ford Motor Co. executive became another expatriate to leave China because of the country's notoriously bad air. Other top executives whose careers would be boosted by a stint in the world's second-largest economy and most populous consumer market are put off when considering the move.

There is no official data on the numbers leaving because of pollution, but executive recruitment consultants say they are noticing that it is becoming harder to attract top talent to China ? both expats and Chinese nationals educated abroad. The European Chamber of Commerce in China says foreign managers leave for many different reasons but pollution is almost always cited as one of the factors and is becoming a larger concern.

If the polluted skies continue, companies may have to fork out more for salaries or settle for less qualified candidates. Failure to attract the best talent to crucial roles could result in missed commercial opportunities and other missteps.

Poor air quality has also added to the complaints that foreign companies have about operating in China. Even though China's commercial potential remains vast, groups representing foreign companies say doing business is getting tougher due to slowing though still robust economic growth, strict Internet censorship, limits on market access and intellectual property theft.

China's rapid economic development over the last three decades has lifted hundreds of millions out of poverty but also ravaged the environment as heavy industry burgeoned, electricity demand soared and car ownership became a badge of status for the newly affluent in big cities. Health risks from pollution of air, water and soil have become a source of discontent with Communist Party rule among ordinary Chinese.

Foreigners regularly check the air quality readings put out by the U.S. Embassy and consulates on their Twitter feeds when deciding whether to go out for a run or let their children play outside.

The pollution has become even more of a hot topic since January, when the readings in Beijing went off the scale and beyond what is considered hazardous by the U.S. Environmental Protection Agency. On the worst days, skyscrapers disappeared into the capital's murky skyline and masks multiplied on the streets and sold out at convenience stores. At the same time, China's state media gave unprecedented coverage to the pollution following months of growing pressure from a Chinese middle class that has become more vocal about the quality of its air.

"January was probably the worst," said Australian Andrew Moffatt, who worked for nine months in Beijing as regional manager for a chain of language schools before the pollution pushed him to return to Brisbane in March with his wife and 5-year-old son.

"Back in November I had been sick and then we went on holiday to the beach in Hainan and it just reminded me of Australia and I just thought we could be breathing this quality air every single day rather than polluted air in Beijing," he said.

And it's not only Beijing where the air pollution is driving expats away.

Ford transferred its regional headquarters from Bangkok to Shanghai in 2009. Four months after the move, Small, the director of communications, had her first major asthma attack.

"I had never had asthma in my life, never ever had asthma before China," said Small, who quit the country in May last year. Her asthma was exacerbated by an allergy to coal, which is the source of about 70 percent of China's energy. Her allergy was first identified in 2005 after a six-week assignment in Beijing ended with her being hospitalized for three days in Hong Kong with her lung function at about 30 percent.

In Shanghai, the asthma resurfaced. "Three hospitalizations later, my doctor said it was time to call it quits," she said.

Her frequent treatments ? involving inhalers, steroids and a nebulizer in the mornings and evenings to get medication deep into her lungs ? meant the medication became less effective.

"I actually got a written warning from my pulmonary doctor and it said you need to reconsider for your life's sake what you're doing and so that was it. I didn't really have a choice, my doctor made it for me."

Ivo Hahn, the CEO of the China office of executive search consultants Stanton Chase, said that in the last six months, air pollution has become an issue for candidates they approach.

"It pops up increasingly that people say 'well we don't want to move to Beijing' or 'I can't convince my family to move to Beijing'," he said. Two expats, one Western and one an overseas Chinese, recently turned down general manager and managing director positions because of the air pollution, he said.

Hahn thinks this trend will only strengthen over the next one or two years because the highest-level executives generally "are not working primarily for their survival."

"They normally get a decent pay, they are generally reasonably well taken care of, so the quality of life actually it does matter, particularly when they have children," he said.

Some, however, say that China has become too important economically for up-and-coming corporate executives to ignore. It generates a large and growing share of profits for global companies while still offering a vast untapped potential. Its auto industry, now the world's largest by number of vehicles sold, is expected to outstrip the U.S. and Europe combined by 2020 as car ownership rises from a low level of 50 vehicles per 1,000 people.

"It's increasingly important for people who want to have careers as managers in multinational companies to have international experience and as part of their career path, and in terms of international experience, China is one of the most desirable places because of the size of the market and growth and dynamism of the market," said Christian Murck, the president of the American Chamber of Commerce in China.

Carl Hopkins, Asia managing partner of legal search firm Major, Lindsey & Africa, said Chinese nationals who had studied abroad at top universities or business schools were reluctant to return unless they had elderly family to take care of.

"There is an unwillingness for these people to return to China because they have got a better standard of living in the States or somewhere else than going to Beijing and Shanghai with its current issues with pollution," Hopkins said, adding that this had become more prevalent over the last year.

Hahn said the effects of expats refusing to relocate to China aren't going to be felt overnight, but eventually "either companies will have to pay a higher price overall because maybe candidates may have to commute as an example, or they may lower their standards or they may offer the position to somebody who may actually not be quite as qualified."

If the current trend hardens, it would have some economic impact, said Alistair Thornton, senior China economist at IHS in Beijing.

"Expats contribute almost nothing to China's growth because the numbers are just tiny, but intangibly they contribute quite a significant amount" by introducing foreign technology, best practices and Western management techniques "that Chinese companies are harnessing and using to drive growth," said Thornton.

He is leaving Beijing in June with air pollution one factor.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2013-04-30-China-Expats%20Leaving/id-15db8b2db5e44edca3d6c6310535ae63

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How we decode 'noisy' language in daily life: How people rationally interpret linguistic input

Apr. 29, 2013 ? Suppose you hear someone say, "The man gave the ice cream the child." Does that sentence seem plausible? Or do you assume it is missing a word? Such as: "The man gave the ice cream to the child."

A new study by MIT researchers indicates that when we process language, we often make these kinds of mental edits. Moreover, it suggests that we seem to use specific strategies for making sense of confusing information -- the "noise" interfering with the signal conveyed in language, as researchers think of it.

"Even at the sentence level of language, there is a potential loss of information over a noisy channel," says Edward Gibson, a professor in MIT's Department of Brain and Cognitive Sciences (BCS) and Department of Linguistics and Philosophy.

Gibson and two co-authors detail the strategies at work in a new paper, "Rational integration of noisy evidence and prior semantic expectations in sentence interpretation," published today in the Proceedings of the National Academy of Sciences.

"As people are perceiving language in everyday life, they're proofreading, or proof-hearing, what they're getting," says Leon Bergen, a PhD student in BCS and a co-author of the study. "What we're getting is quantitative evidence about how exactly people are doing this proofreading. It's a well-calibrated process."

Asymmetrical strategies

The paper is based on a series of experiments the researchers conducted, using the Amazon Mechanical Turk survey system, in which subjects were presented with a series of sentences -- some evidently sensible, and others less so -- and asked to judge what those sentences meant.

A key finding is that given a sentence with only one apparent problem, people are more likely to think something is amiss than when presented with a sentence where two edits may be needed. In the latter case, people seem to assume instead that the sentence is not more thoroughly flawed, but has an alternate meaning entirely.

"The more deletions and the more insertions you make, the less likely it will be you infer that they meant something else," Gibson says. When readers have to make one such change to a sentence, as in the ice cream example above, they think the original version was correct about 50 percent of the time. But when people have to make two changes, they think the sentence is correct even more often, about 97 percent of the time.

Thus the sentence, "Onto the cat jumped a table," which might seem to make no sense, can be made plausible with two changes -- one deletion and one insertion -- so that it reads, "The cat jumped onto a table." And yet, almost all the time, people will not infer that those changes are needed, and assume the literal, surreal meaning is the one intended.

This finding interacts with another one from the study, that there is a systematic asymmetry between insertions and deletions on the part of listeners.

"People are much more likely to infer an alternative meaning based on a possible deletion than on a possible insertion," Gibson says.

Suppose you hear or read a sentence that says, "The businessman benefitted the tax law." Most people, it seems, will assume that sentence has a word missing from it -- "from," in this case -- and fix the sentence so that it now reads, "The businessman benefitted from the tax law." But people will less often think sentences containing an extra word, such as "The tax law benefitted from the businessman," are incorrect, implausible as they may seem.

Another strategy people use, the researchers found, is that when presented with an increasing proportion of seemingly nonsensical sentences, they actually infer lower amounts of "noise" in the language. That means people adapt when processing language: If every sentence in a longer sequence seems silly, people are reluctant to think all the statements must be wrong, and hunt for a meaning in those sentences. By contrast, they perceive greater amounts of noise when only the occasional sentence seems obviously wrong, because the mistakes so clearly stand out.

"People seem to be taking into account statistical information about the input that they're receiving to figure out what kinds of mistakes are most likely in different environments," Bergen says.

Reverse-engineering the message

Other scholars say the work helps illuminate the strategies people may use when they interpret language.

"I'm excited about the paper," says Roger Levy, a professor of linguistics at the University of California at San Diego who has done his own studies in the area of noise and language.

According to Levy, the paper posits "an elegant set of principles" explaining how humans edit the language they receive. "People are trying to reverse-engineer what the message is, to make sense of what they've heard or read," Levy says.

"Our sentence-comprehension mechanism is always involved in error correction, and most of the time we don't even notice it," he adds. "Otherwise, we wouldn't be able to operate effectively in the world. We'd get messed up every time anybody makes a mistake."

The study was supported by a grant from the National Science Foundation.

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The above story is reprinted from materials provided by Massachusetts Institute of Technology. The original article was written by Peter Dizikes.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/_IIiQYNk9ww/130429164950.htm

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N.Y. judge says he may allow Empire State Building REIT plan

By Ilaina Jonas

(Reuters) - A New York judge said on Monday he was leaning toward allowing a group that wants to roll the Empire State Building into a real estate investment trust to force any holdouts to surrender their holdings for a fraction of their value.

New York Supreme Court Justice O. Peter Sherwood said he would issue his written decision regarding Malkin Holdings' plan for the landmark building by the end of Tuesday at the latest.

Under the plan, the Empire State Building - owned by Empire State Building Associates LLC, an entity controlled by Malkin - would join at least 18 other properties in the REIT called Empire State Realty Trust Inc and launch an initial public stock offering.

The plan requires support from 80 percent of each of the three groups of investors who as early as 1961 put money in the entity that became the limited liability company. For four decades after its completion in 1931, the building ranked as the world's tallest building.

Last month Malkin filed regulatory documents that said it had garnered about 95 percent of the investor votes it needs to cross the 80 percent threshold.

Once Malkin reaches that threshold, it claims the right to force any remaining investors to sell back their stakes for $100 each unless they drop their opposition. The units, now held by 2,824 investors, could be worth more than $320,000 apiece if the REIT becomes publicly traded.

The decision under consideration by Justice Sherwood involves that provision. Opponents of the REIT plan contend that Malkin lost the right to force holdouts to sell their holdings in 2001, when he converted Empire State Building Associates into a limited liability company from a partnership.

A REIT is a property or mortgage company that is exempt from corporate income taxes if it distributes at least 90 percent of its taxable income to shareholders in the form of dividends.

(Reporting By Ilaina Jonas; Editing by Gerald E. McCormick and Andrew Hay)

(This story was refiled to change three-quarters to 95 percent in the In fifth paragraph)

Source: http://news.yahoo.com/n-y-judge-says-may-allow-empire-state-152413371.html

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Last pieces of One World Trade Center are rising

NEW YORK (AP) ? One World Trade Center already is New York's tallest building.

And when the last pieces of its spire rise to the roof ? weather permitting ? the 104-floor skyscraper that replaces the fallen twin towers will be just feet from becoming the highest in the Western Hemisphere.

The Port Authority of New York and New Jersey says the spire pieces plus a steel beacon will then be lifted at a later date from the rooftop to cap the building at 1,776 feet.

Installation of the 800-ton, 408-foot spire began in December, after 18 pieces were shipped from Canada and New Jersey.

The spire will serve as a world-class broadcast antenna.

With the beacon at its peak to ward off aircraft, the spire will provide public transmission services for television and radio broadcast channels that were destroyed on Sept. 11, 2001, along with the trade center towers.

Overlooking the Statue of Liberty and Ellis Island, the high-rise is scheduled to open for business in 2014.

The tower is at the northwest corner of the site, which is well on its way to reconstruction with the 72-story 4 World Trade Center and other buildings.

Monday's celebration of the reconstructed trade center comes days after a grisly reminder of the terror attack that took nearly 3,000 lives: the discovery of a rusted piece of airplane landing gear wedged between a nearby mosque and an apartment building ? believed to be from one of the hijacked planes that ravaged lower Manhattan.

As officials prepared to erect the spire, the office of the city's chief medical examiner was working in the hidden alley where debris may still contain human remains.

The new tower's crowning spire is a joint venture between the ADF Group Inc. engineering firm in Terrebonne, Quebec, and New York-based DCM Erectors Inc., a steel contractor.

The world's tallest building, topping 2,700 feet, is in Dubai.

Source: http://news.yahoo.com/last-pieces-1-world-trade-center-rising-063927510.html

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Cancer studies often lack necessary rigor to answer key questions

Public release date: 29-Apr-2013
[ | E-mail | Share ]

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

DURHAM, N.C. Fueled in part by an inclination to speed new treatments to patients, research studies for cancer therapies tend to be smaller and less robust than for other diseases.

This raises some questions about how cancer therapies will work in practice, according to researchers at Duke Medicine, who published an analysis of nearly 9,000 oncology clinical research studies online April 29, 2013, in the journal JAMA Internal Medicine. The studies they looked at were registered on the ClinicalTrials.gov website from 2007-10.

The analysis is part of the Clinical Trials Transformation Initiative, a public-private partnership founded by the U.S. Food and Drug Administration and Duke University to identify and promote practices to improve clinical research.

"We need to understand the strengths and weaknesses of the clinical studies in oncology," said Bradford Hirsch, M.D., assistant professor of medicine and lead author of the study. "There are a lot of reasons for why cancer studies are different than those for other illnesses cancer is a very grave disease and for a long time there weren't a lot of treatment options. But what we're trying to understand is if those differences justify differences in the clinical research being conducted."

Hirsch and colleagues found that oncology clinical research studies were predominantly small, early phase trials that evaluate a single treatment without comparing it to other therapies. Larger, more rigorous trials randomly assign patients to different treatments, "blinding" both doctors and patients from knowing who received the investigational therapy in an effort to eliminate bias.

This orientation toward less robust design differs significantly from other areas of medicine. The trend is partially explained by the accelerated approval process embraced by the FDA since 1992 to improve access to treatments for life-threatening diseases such as cancer. As part of that process, early-phase clinical research studies often measure goals other than extending survival.

In addition, drugs marketed for one use and used "off label" for others have less stringent requirements for winning additional regulatory approvals.

"An inherent tension arises between the desire to use new, life-saving treatments and the imperative to develop the evidence that patients, clinicians, regulatory agencies, and advocacy groups need to make sound decisions." Hirsch said. "Unfortunately, the high prevalence of small studies that lack rigor limits the ability to assess the evidence supporting specific treatments."

Hirsch said the analysis also brought to light some disparities between the incidence and mortality of some cancer types, and the volume of clinical research being conducted. For example, lung cancer has the highest incidence, with 14.5 percent of all new diagnoses and 27.6 percent of all cancer deaths in 2010, but was the focus of only 9.2 percent of studies on the register. Meanwhile, lymphoma was the focus of 6.6 percent of studies, while it represents 4.8 percent of cancer cases and 3.8 percent of deaths.

"People who enroll in clinical trials expect their participation to lead to future benefits for patients," said Nancy Roach, chair of the board of directors for Fight Colorectal Cancer. "Small, single-institution trials are not likely to change the standard of care. I see this paper as a call to action to encourage academic institutions to collaborate with each other on more robust trials that may ultimately lead to clinical benefit."

###

In addition to Hirsch, study authors include Robert M. Califf, Steven K. Cheng, Asba Tasneem, John Horton, Karen Chiswell, Kevin A. Schulman, David M. Dilts and Amy P. Abernethy.

Financial support was provided by a grant from the FDA to Duke University for the Clinical Trials Transformation Initiative.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 29-Apr-2013
[ | E-mail | Share ]

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center

DURHAM, N.C. Fueled in part by an inclination to speed new treatments to patients, research studies for cancer therapies tend to be smaller and less robust than for other diseases.

This raises some questions about how cancer therapies will work in practice, according to researchers at Duke Medicine, who published an analysis of nearly 9,000 oncology clinical research studies online April 29, 2013, in the journal JAMA Internal Medicine. The studies they looked at were registered on the ClinicalTrials.gov website from 2007-10.

The analysis is part of the Clinical Trials Transformation Initiative, a public-private partnership founded by the U.S. Food and Drug Administration and Duke University to identify and promote practices to improve clinical research.

"We need to understand the strengths and weaknesses of the clinical studies in oncology," said Bradford Hirsch, M.D., assistant professor of medicine and lead author of the study. "There are a lot of reasons for why cancer studies are different than those for other illnesses cancer is a very grave disease and for a long time there weren't a lot of treatment options. But what we're trying to understand is if those differences justify differences in the clinical research being conducted."

Hirsch and colleagues found that oncology clinical research studies were predominantly small, early phase trials that evaluate a single treatment without comparing it to other therapies. Larger, more rigorous trials randomly assign patients to different treatments, "blinding" both doctors and patients from knowing who received the investigational therapy in an effort to eliminate bias.

This orientation toward less robust design differs significantly from other areas of medicine. The trend is partially explained by the accelerated approval process embraced by the FDA since 1992 to improve access to treatments for life-threatening diseases such as cancer. As part of that process, early-phase clinical research studies often measure goals other than extending survival.

In addition, drugs marketed for one use and used "off label" for others have less stringent requirements for winning additional regulatory approvals.

"An inherent tension arises between the desire to use new, life-saving treatments and the imperative to develop the evidence that patients, clinicians, regulatory agencies, and advocacy groups need to make sound decisions." Hirsch said. "Unfortunately, the high prevalence of small studies that lack rigor limits the ability to assess the evidence supporting specific treatments."

Hirsch said the analysis also brought to light some disparities between the incidence and mortality of some cancer types, and the volume of clinical research being conducted. For example, lung cancer has the highest incidence, with 14.5 percent of all new diagnoses and 27.6 percent of all cancer deaths in 2010, but was the focus of only 9.2 percent of studies on the register. Meanwhile, lymphoma was the focus of 6.6 percent of studies, while it represents 4.8 percent of cancer cases and 3.8 percent of deaths.

"People who enroll in clinical trials expect their participation to lead to future benefits for patients," said Nancy Roach, chair of the board of directors for Fight Colorectal Cancer. "Small, single-institution trials are not likely to change the standard of care. I see this paper as a call to action to encourage academic institutions to collaborate with each other on more robust trials that may ultimately lead to clinical benefit."

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In addition to Hirsch, study authors include Robert M. Califf, Steven K. Cheng, Asba Tasneem, John Horton, Karen Chiswell, Kevin A. Schulman, David M. Dilts and Amy P. Abernethy.

Financial support was provided by a grant from the FDA to Duke University for the Clinical Trials Transformation Initiative.

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Source: http://www.eurekalert.org/pub_releases/2013-04/dumc-cso042513.php

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This Is How NASA Is Testing the Supersonic Airplanes of the Future

This might look like some kind of space ship?but it's actually a model of a supersonic Boeing airliner, being tested in NASA's Glenn Research Center in Cleveland, Ohio.

The NASA team is working out how to reduce the incredible amount of noise that a supersonic airliner generates. NASA explains:

"We are testing overall vehicle design and performance options to reduce emissions and noise, and identifying whether the volume of sonic booms can be reduced to a level that leads to a reversal of the current ruling that prohibits commercial supersonic flight over land."

That's why the engines are on top of the plane?to shield the ground from noise?and also explains the presence of the funky V-tail channels. They help direct the sonic boom the aircraft creates backwards, to give it longer to dissipate and in turn protect our little ears down on the surface of the Earth. Good job, NASA. [NASA via New Scientist]

Image by NASA

Source: http://gizmodo.com/5995499/this-is-how-nasa-is-testing-the-supersonic-planes-of-the-future

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This Is How NASA Is Testing the Supersonic Airplanes of the Future

This might look like some kind of space ship?but it's actually a model of a supersonic Boeing airliner, being tested in NASA's Glenn Research Center in Cleveland, Ohio.

Read more...

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/PjGrhKOuZVE/this-is-how-nasa-is-testing-the-supersonic-planes-of-the-future

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Militants kill five Iraqi soldiers, Sunni protesters form "army"

By Kamal Naama

RAMADI, Iraq (Reuters) - Militants shot dead five Iraqi soldiers in the Sunni Muslim stronghold province of Anbar on Saturday and protesters said they were forming an "army" after four days of unrest that raised fears of a return to widespread sectarian civil conflict.

More than 170 people have been killed since Tuesday when security forces stormed a Sunni protest camp in the town of Hawija, triggering clashes that spread to other Sunni areas in western and northern areas.

Sunnis have been demonstrating since December against the perceived marginalization of their sect under Iraq's Shi'ite Muslim-led government.

A curfew was imposed on the city of Ramadi in Anbar, a western province, on Saturday after militants killed five soldiers who authorities said were returning from holiday to their units. Protesters said they had been sent to attack them.

Protests had eased recently, but the army raid earlier this week in Hawija, near the city of Kirkuk, 170 km (100 miles) north of Baghdad, reignited Sunni discontent and may have given fresh impetus to insurgents.

"In order to keep Anbar a safe place for the Sunnis, we decided to form an army called the Army of Pride and Dignity with 100 volunteers from each tribe to protect our province," said Sheikh Saeed Al-Lafi, a spokesman for the protesters.

Lafi said police and members of the Iraqi army were welcome to join their ranks.

Influential Sunni cleric Sheikh Abdul Malik Al-Saadi, who had previously taken a conciliatory stance and urged restraint, on Saturday congratulated the "honorable Iraqi mujahideen (holy warriors)" on the proclaimed creation of the regional army.

At least four members of a government-backed Sunni "Sahwa" militia were killed when gunmen opened fire at a checkpoint in Awja, outside Tikrit. Police and militants battled in Baiji, a former bastion of Sunni jihadist al Qaeda, about 180 km (112 miles) north of Baghdad.

In the Abu Ghraib district of Baghdad, four soldiers were killed early on Saturday in clashes with unidentified gunmen.

KURDISH TROOPS DEPLOY

Relations between the central government and ethnic Kurds, who run their own administration in the north, have also been frayed by an ongoing row over land and oil rights.

Kurdish security forces deployed beyond the formal boundary of their autonomous region overnight, a move they said was to protect civilians in the oil-rich territory over which both the Kurds and Baghdad claim jurisdiction.

At the heart of that disputed area is the ethnically mixed city of Kirkuk.

"After the incident in Hawija created an unstable situation in the area, especially around Kirkuk city and ... all disputed areas ... military units mobilized from their bases," spokesman Jabbar Yawar said on his Facebook page.

The Iraqi army and Kurdish troops, known as peshmerga, are facing off along their contested internal boundary following a military build-up late last year.

Yawar said the deployment was based on information that "terrorists" were planning to take advantage of the volatile situation to carry out attacks in the area, but said the peshmerga had no plans to enter Kirkuk or any other cities.

"There are no political intentions behind this plan. The sole objective is to protect the lives and possessions of civilians," Yawar said.

(Additional reporting by Raheem Salman and Ahmed Rasheed in Baghdad, Ghazwan Hassan in Tikrit, and Isabel Coles in Arbil; Editing by Robin Pomeroy)

Source: http://news.yahoo.com/militants-kill-five-iraq-soldiers-sunni-protesters-form-160738767.html

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Pale Plague

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It began 40 years ago. A plague which turns man and beast into monstrous beings. Somehow, many humans survived the plague, but it continues to spread. Now, only the Plague Doctors can help.

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The people shouldn't be afraid of their government.
The government should be afraid of their people.

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I-Team: Sandy Flood Coverage Denied via ?Sinkhole Loophole ...

Six months after Sandy flooded homes and businesses throughout the area, New York insurance regulators are getting flooded with complaints about insurance coverage.

Deborah Schochet of Woodmere filed a complaint after her flood coverage was denied when an adjuster determined that the damage to her home was caused by a sinkhole beneath the foundation and not specifically flood water.

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The problem ? the driving wind, rain and rushing water from Sandy created that sinkhole.

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?It made absolutely no sense,? said Schochet. ?It was a loophole for them to get out of paying what they should be paying.?

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Schochet, who is battling Lou Gehrig?s disease, has to navigate her damaged home each day, with a gaping hole in the basement floor, lack of central heat and water-logged drywall.?

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?I fully paid my premiums and I deserve to be paid,? said Schochet.

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Allstate Insurance manages her policy and denied the claim based on a little-known clause in the National Flood Insurance Program. The clause allows adjusters to claim the damage was actually caused by soil erosion and not flood water ? even if the flood water caused the soil erosion.

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The NFIP is a government program. Private insurance companies handle the individual policies for customers and approve or deny coverage based on the federal government?s regulations.

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?The sinkhole is a bogus excuse for them not to pay,? said Schochet.

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In a statement, April Eaton of Allstate Insurance said, ?Allstate is legally bound by the rules, regulations and policy language set forth by the NFIP, which pays the claims. We are in close contact with NFIP on this case, and understand the claim is under additional review by the NFIP.?

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Since Sandy, more than 3,388 New Yorkers have filed official complaints with the state against their insurance companies.

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As a whole, Allstate has the most complaints in New York, but the company also writes the most policies in the state. Eaton, citing FEMA statistics, said in her statement that Allstate had the best score on timely administration of flood insurance claims following Sandy, totaling more than $718 million.

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When the state list of complaints is broken down per claim, Assurant Insurance tops it with nearly two complaints for every 100 claims, followed by Tower, Narragansett Bay Insurance and QBE.

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QBE denied nearly one-third of all its claims since Sandy.

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Through a spokeswoman, the company said 11 complaints were mistakenly tied to QBE and ?there are at least three additional complaints which we believe should not be attributed to QBE. We are talking with the department about these.?

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The superintendent of New York?s Department of Financial Services, Benjamin Lawsky, said any insurance company generating a lot of complaints will grab his department?s attention.

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"If there is a high rate of complaints, not only should individuals be worried about it, but we're worried about it," said Lawsky.

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His department handles insurance complaints in New York. He explained many of the issues that angered New Yorkers.

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?Companies were not there to take people?s calls, they were not getting adjusters out to homes fast enough and they weren?t resolving claims fast enough,? said Lawsky.

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Michael Barry of the Insurance Information Institute ? an industry-funded research group ? says 3,000 complaints after a catastrophic event is not usual and said insurers have resolved 93 percent of Sandy-related claims in the last six months.

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"When you look at the number of claims and the claims' payouts, we're talking about hundreds of thousands of claims and billions of dollars out the door,? said Barry.

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The I-Team has learned that both Tower and Narragansett Bay are under investigation by state regulators for delays in claims processing.

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A representative from Assurant said his company believes the state's calculations unfairly penalized Assurant because the company handles a high percentage of flood claims.

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Narragansett Bay said in statement it "has closed 98 percent of all claims." The company also disputed the Department of Financial Services' report that it received 215 complaints as of April 19, which resulted in a complaint-to-claim ratio of 1.9 percent. Narragansett Bay said it received 168 complaints, "which totals less than 1.5 percent of total claims in New York."?

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Tower did not return calls for comment.

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The Federal Emergency Management Agency said it is continuing to work with Sandy survivors to recoup their losses. The agency is instructing all flood policy holders who have disputes with the private companies that administer the program to contact FEMA directly by calling 800-427-4661.

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Source: http://www.nbcnewyork.com/investigations/I-Team-Sandy-Flood-Coverage-Denied-via-Sinkhole-Loophole-204880561.html

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Apple in talks with Nuance to bring Swype to iOS

* Lewandowski scored four goals against Real Madrid * Poland international refuses contract extension (adds details, background) BERLIN, April 26 (Reuters) - Bayern Munich and Borussia Dortmund striker Robert Lewandowski have not signed a deal, the newly-crowned champions said on Friday, shooting down widespread speculation of another imminent surprise transfer. "Bayern, as opposed to some reports, has no contract with Robert Lewandowski," the Bavarian Champions League semi-finalists said in a brief statement. ...

Source: http://news.yahoo.com/apple-talks-nuance-bring-swype-ios-151032725.html

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Fossilized bird egg sells at auction for more than $100,000

* Lewandowski scored four goals against Real Madrid * Poland international refuses contract extension (adds details, background) BERLIN, April 26 (Reuters) - Bayern Munich and Borussia Dortmund striker Robert Lewandowski have not signed a deal, the newly-crowned champions said on Friday, shooting down widespread speculation of another imminent surprise transfer. "Bayern, as opposed to some reports, has no contract with Robert Lewandowski," the Bavarian Champions League semi-finalists said in a brief statement. ...

Source: http://news.yahoo.com/blogs/sideshow/fossilized-bird-egg-sells-auction-more-100-000-212736083.html

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Drawnimal, Netflix, and More

Adults shouldn't have all the fun. This week's set of iPad apps includes something for the kids as well as a beloved, improved toy all your very own. More »

Source: http://feeds.gawker.com/~r/gizmodo/full/~3/tNKw40OYY9M/drawnimal-netflix-and-more

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Sunshine hormone, vitamin D, may offer hope for treating liver fibrosis

Apr. 25, 2013 ? Liver fibrosis results from an excessive accumulation of tough, fibrous scar tissue and occurs in most types of chronic liver diseases. In industrialized countries, the main causes of liver injury leading to fibrosis include chronic hepatitis virus infection, excess alcohol consumption and, increasingly, nonalcoholic steatohepatitis (NASH).

Now, in a new study published in the journal Cell, scientists at the Salk Institute for Biological Studies have discovered that a synthetic form of vitamin D, calcipotriol (a drug already approved by the FDA for the treatment of psoriasis), deactivates the switch governing the fibrotic response in mouse liver cells, suggesting a potential new therapy for fibrotic diseases in humans.

"Because there are currently no effective drugs for liver fibrosis, we believe our findings would open a new door for treatment," says senior author Ronald M. Evans, a professor in Salk's Gene Expression Laboratory and lead researcher in the Institute's new Helmsley Center for Genomic Medicine.

The Salk study focused on a star-shaped "stellate" cell in the liver that serves as a beacon for damage. When called into action, stellate cells produce fibrotic proteins in an attempt to heal an injury. Under chronic stress, however, localized fibrosis expands, eventually leading to cirrhosis, increased risk of liver cancer, and the need for a liver transplant in advanced cases.

The Evans lab discovered a genetic switch through which vitamin D-related ligands such as calcitriol, a hormonally active form of the vitamin, can put the brakes on fibrosis. "Preclinical results suggest the 'vitamin D brake' is highly efficacious and led us to believe that the time is right to consider a trial in the context of chronic liver disease," says Evans, a Howard Hughes Medical Institute Investigator and holder of the March of Dimes Chair in Molecular and Developmental Biology.

Previous studies have shown a physiologic role for vitamin D in liver function, but "it was our discovery of high levels of vitamin D receptor (VDR) in the stellate cell that led us to consider it as a possible off switch for liver fibrosis," says lead author Ning Ding, a research associate in the Gene Expression Laboratory.

"Current therapeutic approaches, which treat the symptoms of liver disease, don't stop liver fibrosis from progressing," says Michael Downes, a senior staff scientist in the Gene Expression Laboratory and co-corresponding author on the paper. "In liver diseases where the underlying cause cannot be cured, progression to cirrhosis is currently inevitable in some people. What we have discovered is that by acting on the genome, VDR can simultaneously defend against multiple fibrotic activators. This is important because many different pro-fibrotic signaling pathways converge on the genome to affect their fibrotic response."

The Salk discovery that calcipotriol counters the fibrotic response in stellate cells illuminates a potentially safer, more effective strategy capable of neutralizing multiple convergent fibrotic triggers.

The Salk scientists say that clinical trials of the vitamin D analog for the treatment of liver fibrosis are being planned. The synthetic vitamin D analog is better than natural vitamin D, they say, for a couple of reasons. First, natural vitamin D, which is found in small amounts in a few foods and produced in the body by exposure to sunlight, degrades quickly, while synthetic versions of vitamin D are less susceptible to breakdown. Second, too much natural vitamin D can cause hypercalcemia, or elevated calcium in the blood, which can lead to nausea and vomiting, frequent urination, muscle weakness and joint aches and pain. The synthetic vitamin D analog, on the other hand, produces a strong response without adding calcium to the blood.

In addition, the researchers say this new model for treating liver fibrosis may also be helpful in treating other diseases with a fibrotic component, including those of the lung, kidney and pancreas.

Other researchers on the study were Ruth T. Yu, Mara H. Sherman, Mathias Leblanc, Mingxiao He, Annette R. Atkins and Grant D. Barish, from the Salk Institute; Nanthakumar Subramaniam, Caroline Wilson, Renuka Rao, Sally Coulter and Christopher Liddle, of the University of Sydney (Australia); and Sue L. Lau , Christopher Scott and Jenny E. Gunton, of the Garvan Insitute for Medical Research (Australia).

The work was supported by grants from the National Institutes of Health, the Howard Hughes Medical Institute, the National Health and Medical Research Council of Australia, the Genentech Foundation, the Leona M. and Harry B. Helmsley Charitable Trust, the Samuel Waxman Cancer Research Foundation, Stand Up to Cancer and Ipsen/Biomeasure.

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The above story is reprinted from materials provided by Salk Institute for Biological Studies.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/GZLOXi4a8Bo/130425160125.htm

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